文章基本信息

标题：The antibody catalysis route to the total synthesis of epothilones
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作者：Subhash C. Sinha ; Carlos F. Barbas ; Richard A. Lerner 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：25
页码：14603-14608
DOI：10.1073/pnas.95.25.14603
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：An efficient monoclonal aldolase antibody that proceeds by an enamine mechanism was generated by reactive immunization. Here, this catalyst has been used in the total synthesis of epothilones A (1) and C (3). The starting materials for the synthesis of these molecules have been obtained by using antibody-catalyzed aldol and retro-aldol reactions. These precursors were then converted to epothilones A (1) and C (3) to complete the total synthesis.