文章基本信息

标题：The conducting form of gramicidin A is a right-handed double-stranded double helix
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作者：B. M. Burkhart ; N. Li ; D. A. Langs 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：22
页码：12950-12955
DOI：10.1073/pnas.95.22.12950
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The linear pentadecapeptide antibiotic, gramicidin D, is a naturally occurring product of Bacillus brevis known to form ion channels in synthetic and natural membranes. The x-ray crystal structures of the right-handed double-stranded double-helical dimers (DSDH[R]) reported here agree with 15N-NMR and CD data on the functional gramicidin D channel in lipid bilayers. These structures demonstrate single-file ion transfer through the channels. The results also indicate that previous crystal structure reports of a left-handed double-stranded double-helical dimer in complex with Cs+ and K+ salts may be in error and that our evidence points to the DSDH[R] as the major conformer responsible for ion transport in membranes.