文章基本信息

标题：CTXφ immunity: Application in the development of cholera vaccines
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作者：Harvey H. Kimsey ; Matthew K. Waldor
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：12
页码：7035-7039
DOI：10.1073/pnas.95.12.7035
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：CTX{varphi} is a filamentous bacteriophage that encodes cholera toxin, the principal virulence factor of Vibrio cholerae. CTX{varphi} is unusual among filamentous phages because it encodes a repressor and forms lysogens. CTX{varphi} can infect the existing live-attenuated V. cholerae vaccine strains derived from either the El Tor or classical V. cholerae biotypes and result in vaccine reversion to toxinogenicity. Intraintestinal CTX{varphi} transduction assays were used to demonstrate that El Tor biotype strains of V. cholerae are immune to infection with the El Tor-derived CTX{varphi