文章基本信息

标题：Noninvasive somatosensory homunculus mapping in humans by using a large-array biomagnetometer
本地全文：下载
作者：T T Yang ; C C Gallen ; B J Schwartz 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1993
卷号：90
期号：7
页码：3098-3102
DOI：10.1073/pnas.90.7.3098
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：To validate the feasibility of precise noninvasive functional mapping in humans, a large-array biomagnetometer was used to map the somatosensory cortical locations corresponding to numerous distinct tactile sites on the fingers, hand, arm, and face in different subjects. Source localizations were calculated by using a single equivalent current dipole (ECD) model. Dipole localizations were transposed upon the corresponding subject's magnetic resonance image (MRI) to resolve the anatomic locus of the individual dipoles within a given subject. Biomagnetic measurements demonstrated that (i) there were distinct separations between the ECD locations representing discrete sites on the face and hand; (ii) the ECD localizations from facial sites clustered in a region inferior to ECD localizations from hand and digit sites; and (iii) there was clear spatial resolution of ECD locations representing closely spaced tactile sites on the hand and face. The ability of magnetoencephalography (MEG) to provide high-resolution spatial maps of the somatosensory system noninvasively in humans should make MEG a useful tool to define the normal or pathological organization of the human somatosensory system and should provide an approach to the rapid detection of neuroplasticity.