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  • 标题:Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens.
  • 本地全文:下载
  • 作者:L Nitschke ; M H Kosco ; G Köhler
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1993
  • 卷号:90
  • 期号:5
  • 页码:1887-1891
  • DOI:10.1073/pnas.90.5.1887
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:To examine the in vivo function of IgD we generated mice deficient for IgD by gene targeting. The IgD-mice show a reduced B-cell compartment with 30-50% less B cells in the spleen and lymph nodes but show a normal pre-B-cell compartment. The surface-IgD- B cells express two to three times more surface IgM than B cells of control animals. Serum concentrations of the immunoglobulin isotypes of IgD- mice are almost normal, indicating that surface-IgD expression is not necessary for class switching of B cells. Immunization experiments showed that IgD- mice could respond well to thymus-dependent and -independent antigens. After immunization normal germinal centers developed in the IgD- mice. These data suggest that IgD is not necessary for the induction of immune responses but may be important in homeostasis of cells in the B-cell compartment.
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