文章基本信息

标题：Retinoic acid-induced duplication of the zebrafish retina
本地全文：下载
作者：G A Hyatt ; E A Schmitt ; N R Marsh-Armstrong 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1992
卷号：89
期号：17
页码：8293-8297
DOI：10.1073/pnas.89.17.8293
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Exogenous treatment of zebrafish embryos with retinoic acid induces a duplication of the retinas during development. These effects occur only when retinoic acid is applied within a 2-hr period prior to and during the initial formation of the optic primordia, and they are concentration-dependent. Light microscopic examination reveals that the second retina derives from cells in the ventral region of the developing eyecup that normally become pigment epithelial cells. Two distinct ganglion cell fields are usually observed in eyes with duplicated retinas. Bundles of axons from each ganglion cell field join as they leave the eye and innervate the contralateral tectum.