文章基本信息

标题：DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.
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作者：M A White ; M Wierdl ; P Detloff 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1991
卷号：88
期号：21
页码：9755-9759
DOI：10.1073/pnas.88.21.9755
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：In the yeast Saccharomyces cerevisiae, as in other eukaryotes, some regions of the genome have a much higher rate of meiotic recombination than others. We show below that the binding of the RAP1 protein to a site upstream of the HIS4 gene is necessary for a high rate of meiotic (but not mitotic) recombination at this locus. A mutation in the RAP1 binding site at HIS4 results in a decrease in recombination; overproduction of RAP1 causes an increase in recombination at HIS4 above wild-type levels.