文章基本信息

标题：Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins.
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作者：K A Wharton ; G H Thomsen ; W M Gelbart 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1991
卷号：88
期号：20
页码：9214-9218
DOI：10.1073/pnas.88.20.9214
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The 60A gene, a member of the transforming growth factor beta superfamily of signaling proteins, has been identified in Drosophila melanogaster. From its inferred protein sequence we predict the precursor is secreted and processed to release a growth factor-like molecule. The 60A gene is expressed throughout development with peaks of transcription during early embryogenesis, in pupae, and in adult males. The putative 60A protein shows greater sequence similarity to three vertebrate family members (human bone morphogenetic proteins 5, 6, and 7) than to its only Drosophila relative, the protein product of the decapentaplegic (dpp) gene. This observation suggests that the duplication event that gave rise to the two transforming growth factor beta-like proteins in Drosophila predates the divergence of chordates and arthropods.