文章基本信息

标题：Centrioles in the beginning of human development
本地全文：下载
作者：A H Sathananthan ; I Kola ; J Osborne 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1991
卷号：88
期号：11
页码：4806-4810
DOI：10.1073/pnas.88.11.4806
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We demonstrate the presence of centrioles in fertilized human oocytes at syngamy. Single or double centrioles within centrosomes were detected by transmission electron microscopy at one pole of the first cleavage spindle in normal and dispermic embryos (25-26 hr after insemination). Sperm centrioles were also closely associated with the male pronucleus (16-20 hr after insemination) in pronuclear stage embryos. A tripolar spindle derived from a tripronuclear embryo is also demonstrated with two centrioles at one pole. The data provide evidence that human centrioles, as those in most other animals, and unlike the mouse, are paternally derived, thus supporting Boveri's classical theory. Furthermore, this study provides insights to the proposed mechanisms of aberrant cleavage patterns of dispermic human embryos.