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  • 标题:Piliation control mechanisms in Neisseria gonorrhoeae
  • 本地全文:下载
  • 作者:S Bergström ; K Robbins ; J M Koomey
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1986
  • 卷号:83
  • 期号:11
  • 页码:3890-3894
  • DOI:10.1073/pnas.83.11.3890
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Gonococci (Gc) undergo pilus+ to pilus- "phase transitions" readily in vitro. In the present study we sequenced pilin mRNA from reverting, pilus- Gc by oligonucleotide primer extension and compared these pilin mRNA sequences with those expressed by their pilus+ predecessors and pilus+ revertants. The results suggest that genetic rearrangement within the pilin structural gene can generate defective pilin gene products, resulting in a pilus- phenotype. These pilus- Gc give rise to pilus+ revertants upon reconstitution of their modified pilin gene.
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