文章基本信息

标题：Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences
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作者：R G Hawley ; M J Shulman ; H Murialdo 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：23
页码：7425-7429
DOI：10.1073/pnas.79.23.7425
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The kappa light chain genes from two mutant hybridoma cell lines defective in kappa light chain synthesis were isolated and compared to the wild-type kappa light chain gene. In each case, the mutant kappa light chain genes were found to contain repetitive DNA elements in their intervening sequences that were not present in the intervening sequences of the wild-type kappa light chain gene. These elements were found to be related to the genes of intracisternal A particles. These results suggest that the decreased production of kappa light chain in the mutant cell lines is due to the presence of the intracisternal A particle-related genes.