文章基本信息

标题：Genetic and molecular diversity in nondeletion Hb H disease
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作者：D R Higgs ; L Pressley ; B Aldridge 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：9
页码：5833-5837
DOI：10.1073/pnas.78.9.5833
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Restriction endonuclease mapping of nondeletion alpha-thalassemia determinants from a variety of racial groups showed no detectable abnormalities within a 40-kilobase region of the zeta-alpha globin gene cluster. By using a zeta-specific probe, we defined three different types of interactions that give rise to Hb H disease, each involving a nondeletion alpha-thalassemia haplotype. mRNA analysis showed further diversity within these groups, indicating that there are at least three nondeletion determinations.