文章基本信息

标题：Is acquired immunological tolerance genetically transmissible?
本地全文：下载
作者：E Nisbet-Brown ; T G Wegmann
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：9
页码：5826-5828
DOI：10.1073/pnas.78.9.5826
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have attempted to verify that acquired characteristics can be transmitted through the male germ line by using as a model system the vertical transmission of specific immunological tolerance to major histocompatibility antigens. Tolerant males were a tetraparental mouse and separated parabionts, in each case showing stable lymphoid chimerism. Tolerance in the progeny was assessed by two in vivo assays, rejection of cardiac allografts and clearance of 131I-labeled tumor cells. We were unable to find evidence for heritability of the tolerant state in tetraparental or parabiont males, with either assay system.