文章基本信息

标题：Polymorphic DNA region adjacent to the 5' end of the human insulin gene
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作者：G I Bell ; J H Karam ; W J Rutter 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：9
页码：5759-5763
DOI：10.1073/pnas.78.9.5759
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The length of a segment of DNA associated with the human insulin gene, which has been localized to the short arm of chromosome 11, is heterozygous in 63% of 52 individuals analyzed. This polymorphic region is approximately 500 base pairs from the nucleotide encoding the 5' end of insulin mRNA. The polymorphism appears to be due to an insertion or deletion of DNA sequences so that DNA fragments of different length are generated when DNA from a heterozygous individual is digested with selected restriction endonucleases.