文章基本信息

标题：An Epstein--Barr virus early protein induces cell fusion
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作者：G J Bayliss ; H Wolf
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：11
页码：7162-7165
DOI：10.1073/pnas.78.11.7162
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Superinfection of Raji cells with Epstein--Barr virus (EBV) leads to syncytium formation. Studies using metabolic inhibitors and amino acid analogues suggest that the fusion-inducing factor belongs to the early group of virus-specified proteins. Induction of early EBV protein synthesis in Raji cells by using various chemicals also leads to syncytium formation, indicating that the fusion process is not caused by a virion membrane protein introduced into the cells upon infection. The relevance of these findings to the association of EBV with carcinoma of the nasopharynx is discussed.