文章基本信息

标题：An amplified sensitivity arising from covalent modification in biological systems
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作者：A Goldbeter ; D E Koshland
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：11
页码：6840-6844
DOI：10.1073/pnas.78.11.6840
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The transient and steady-state behavior of a reversible covalent modification system is examined. When the modifying enzymes operate outside the region of first-order kinetics, small percentage changes in the concentration of the effector controlling either of the modifying enzymes can give much larger percentage changes in the amount of modified protein. This amplification of the response to a stimulus can provide additional sensitivity in biological control, equivalent to that of allosteric proteins with high Hill coefficients.