文章基本信息

标题：Single channel currents induced by complement in antibody-coated cell membranes
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作者：M B Jackson ; C L Stephens ; H Lecar 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：10
页码：6421-6425
DOI：10.1073/pnas.78.10.6421
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：An extracellular patch electrode was used to record ionic currents from individual complement-induced channels in the membranes of antibody-coated skeletal muscle. The amplitude of the single-channel currents leads to an estimate of 90 pS for the unit conductance. The kinetics of channel opening and closing show marked variability and complexity. Channels flicker open and closed repeatedly, indicating that once these lesions form, they undergo rapid structural transitions between discrete conducting and nonconducting states.