文章基本信息

标题：Genetic control of major histocompatibility complex-linked immune responses to synthetic polypeptides in man
本地全文：下载
作者：S H Hsu ; M M Chan ; W B Bias 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：1
页码：440-444
DOI：10.1073/pnas.78.1.440
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Vigorous lymphocyte proliferative response to synthetic polypeptides was observed in cells from 50 normal volunteers. Results indicated that 64% responded to poly(LHis, LGlu)-poly(DLAla)--poly(LLys) [(H, G)-A--L] and 54% to poly(LTyr, LGlu)-poly(DLAla)--poly(LLys) [(T, G)-A--L]. Subjects could be classified into high-, intermediate-, and non-responder phenotypes according to their stimulation indices. Family studies indicated that high responses to these antigens are inherited as histocompatibility antigen gene (HLA)-linked dominant traits. Two matings suggested gene complementation in response to (T, G)-A--L and (H, G)-A--L. One, with an intra-HLA recombinant offspring, provided evidence localizing the immune response gene(s) controlling lymphocyte proliferation to (T, G)-A--L and (H, G)-A--L, presumably the homologue to Ir-1 of mouse, closer to the HLA-B than to the HLA-D region.