文章基本信息

标题：Peptide inhibitor of morphine- and beta-endorphin-induced analgesia
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作者：N M Lee ; H J Friedman ; L Leybin 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：9
页码：5525-5526
DOI：10.1073/pnas.77.9.5525
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The synthetic beta-endorphin analogs with the omission of the NH2-terminal [Met]enkephalin segment [beta-endorphin-(6-31) and beta-endorphin-(20-31)] are shown to inhibit morphine- or beta-endorphin-induced analgesia in mice by the tail-flick test, whereas the synthetic NH2-terminal pentadecapeptide beta-endorphin-(1-15) has no inhibitory activity. This study raises the possibility that endogenous inhibiting peptides exist in the brain which play a role in the regulation of endorphin actions.