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标题：Activation of membrane-bound kallikrein and renin in the kidney
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作者：K Nishimura ; F Alhenc-Gelas ; A White 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：8
页码：4975-4978
DOI：10.1073/pnas.77.8.4975
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Rat kidney contains membrane-bound renin (EC 3.4.99.19 ) and kallikrein (EC 3.4.21.8 ). Kallikrein activity was measured by a spectrophotometric assay and renin by radioimmunoassay. Plasma membrane-bound kallikrein was activated by lysolecithin and by melittin, which was a more potent activator., This activation by mellitin was independent of calcium concentration. Mellitin was, however, a more potent activator of membrane-bound renin in the presence of calcium. Administration of aldosterone to rats for 6 days increased kallikrein activity in the renal homogenate and in the membrane-enriched fractions, whereas renin activity was not affected. It was proposed that kallikrein may also be located on the basal membrane of tubular epithelial cells, where aldosterone can enhance its activity.