文章基本信息

标题：Association of the src gene product of Rous sarcoma virus with cytoskeletal structures of chicken embryo fibroblasts
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作者：J G Burr ; G Dreyfuss ; S Penman 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：6
页码：3484-3488
DOI：10.1073/pnas.77.6.3484
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have prepared cytoskeletons from normal and Rous sarcoma virus-transformed cells by extraction with nonionic detergents in a buffered salt solution designed to preserve the structure as it exists in vivo. Virtually all of the phosphoprotein pp60src in the cell is bound to such cytoskeletons. Furthermore, when these cytoskeletons are incubated in situ with [gamma-32P]ATP, pp60src is phosphorylated. Labeling of other apparently transformation-specific cytoskeletons phosphoproteins is also observed. These results directly demonstrate an association between pp60src and elements of the cytoskeleton and suggest that pp60src may exert at least some of its effects as a consequence of its interaction with this cellular framework.