文章基本信息

标题：Sequential medical trials
本地全文：下载
作者：T. L. Lai ; Bruce Levin ; Herbert Robbins 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：6
页码：3135-3138
DOI：10.1073/pnas.77.6.3135
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A model for sequential clinical trials is discussed. Three proposed stopping rules are studied by the Monte Carlo method for small patient horizons and mathematically for large patient horizons. They are shown to be about equally effective and asymptotically optimal from both Bayesian and frequentist points of view and are markedly superior to any fixed sample size procedure.
关键词：stopping rules ; asymptotic optimality