文章基本信息

标题：No apparent nucleotide sequence specificity in cellular DNA juxtaposed to retrovirus proviruses
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作者：K Shimotohno ; H M Temin
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：12
页码：7357-7361
DOI：10.1073/pnas.77.12.7357
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The sequences of the virus-cell junctions of seven DNA clones of spleen necrosis virus provirus were analyzed to determine the nucleotide sequence specificity of the cellular integration sites. As previously reported for one provirus, all clones contain a 5-base-pair direct repeat of cellular DNA at the cell-virus junctions and a 3-base-pair inverted repeat at both ends of the provirus DNA. The sequences of the 5-base-pair direct repeats are different in each clone and have no apparent homology to viral DNA. No apparent common features and no sequences significantly homologous to the ends of the provirus DNA were found in the cellular DNAs surrounding the viral integration sites.