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标题：Cloning and complete nucleotide sequence of human 5'-alpha-globin gene
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作者：S A Liebhaber ; M J Goossens ; Y W Kan 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：12
页码：7054-7058
DOI：10.1073/pnas.77.12.7054
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have cloned one of the two human alpha-globin genes and report its complete nucleotide sequence. The gene is 832 base pairs (bp) long from the 5'-cap site to the 3'-polyadenylylation site. The amino acid coding sequences are separated into three segments (exons) by two short (117 and 140 bp) intervening sequences. Highly conserved regions are identified in the 5'-flanking region, intron-exon junctions, and 3' noncoding regions that may have functional significance.