文章基本信息

标题：Degradation of junctional and extrajunctional acetylcholine receptors by developing rat skeletal muscle
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作者：J H Steinbach ; J Merlie ; S Heinemann 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1979
卷号：76
期号：7
页码：3547-3551
DOI：10.1073/pnas.76.7.3547
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have examined the rate of degradation of the total acetylcholine receptor content of diaphragm muscles of young rats and have found that even in muscles from 1-day-old rats some receptors are metabolically more stable than adult extrajunctional receptors. Further experiments have shown that acetylcholine receptors at junctional regions from young rats are degraded slowly, whereas those in extrajunctional regions are degraded rapidly. The results demonstrate that junctional acetylcholine receptors in rat diaphragm are degraded at a slow rate characteristic of adult junctional receptors at all ages after birth.