文章基本信息

标题：Hybrid resistance to parental bone marrow transplantation: adaptive modification of hemopoietic stem cell in a nonsyngeneic environment
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作者：J L Chertkov ; I M Gelfand ; O A Gurevitch 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1979
卷号：76
期号：6
页码：2955-2959
DOI：10.1073/pnas.76.6.2955
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Defective growth of parental bone marrow in an F1 hybrid is associated with delay of the exponential growth phase of injected hemopoietic stem cells rather than with their rejection. This is demonstrated both by parental hemopoietic stem cell kinetics in the irradiated hybrid and by the increase in the number of spleen colonies with time after hemopoietic cell injection. After passage through an F1 hybrid the parental hemopoietic stem cells acquire ability for better growth in the same F1 host. This phenomenon, which we designated "adaptive modification of hemopoietic stem cells," is associated with the appearance, on their surface, of histocompatibility molecules carrying H-2 determinants of the recipient. Treatment of the modified cells with antiserum against the second parental strain abrogates the state of adaptive modification.