文章基本信息

标题：Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg
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作者：W M Generoso ; K T Cain ; M Krishna 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1979
卷号：76
期号：1
页码：435-437
DOI：10.1073/pnas.76.1.435
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of first-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine, and benzo[a]pyrene treatments; and no difference was found for x-ray treatment.