文章基本信息

标题：Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain
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作者：S Tonegawa ; A M Maxam ; R Tizard 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1978
卷号：75
期号：3
页码：1485-1489
DOI：10.1073/pnas.75.3.1485
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have determined the sequence of the DNA of a germ-line gene for the variable region of a mouse immunoglobulin light chain, the VlambdaII gene. The sequence confirms that the variable region gene lies on the DNA separated from the constant region. Hypervariable region codons appear in the germ-line sequence. A sequence for the hydrophobic leader, 19 amino acids that are cleaved from the amino terminus of the protein, appears near, but not continuous with, the light chain structural sequence: most of the leader sequence is separated from the rest of the gene by 93 bases of untranslated DNA.