文章基本信息

标题：Increased incorporation of adenosine into adenine nucleotide pools in serum-deprived mammalian cells
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作者：E Rapaport ; P C Zamecnik
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1978
卷号：75
期号：3
页码：1145-1147
DOI：10.1073/pnas.75.3.1145
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The effects of serum deprivation on the incorporation of adenosine into the intracellular adenine nucleotide pools by several mamalian cell lines were studied. Cells arrested in the G1 phase of the cell cycle showed increased incorporation of exogenous adenosine into their adenine nucleotide pools as compared with growing cells. This phenomenon is unexpected because salvage pathways from all other preformed nucleosides and bases as well as the de novo synthesis of adenine nucleotides is decreased after arrest of growth by serum deprivation. The incorporation of adenosine into adenine nucleotides may serve as an intracellular signal in the regulation of growth in mammalian cells.