文章基本信息

标题：Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse
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作者：C M Wilson ; E G Erdös ; J D Wilson 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1978
卷号：75
期号：11
页码：5623-5626
DOI：10.1073/pnas.75.11.5623
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Renin activity (EC 3.4.99.19 ) was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.