文章基本信息

标题：Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1)
本地全文：下载
作者：D Solter ; B B Knowles
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1978
卷号：75
期号：11
页码：5565-5569
DOI：10.1073/pnas.75.11.5565
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described. This antibody, which reacts with embryonal carcinoma cells of mouse and human origin and with some preimplantation stage mouse embryos, defines an embryonic stage-specific antigen. This stage-specific antigen (SSEA-1) is first detected on blastomeres of 8-cell stage embryos. Trophectodermal cells are transitorily positive; however, each cell in the inner cell mass eventually expresses this antigen.