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标题：Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neurons
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作者：T. Hökfelt ; L. G. Elfvin ; R. Elde 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1977
卷号：74
期号：8
页码：3587-3591
DOI：10.1073/pnas.74.8.3587
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：By means of the indirect immunofluorescence technique of Coons and collaborators, somatostatin-like immunoreactivity has been demonstrated in principal ganglion cells of some sympathetic ganglia. The noradrenergic nature of these cells was established by "staining" of the same or consecutive sections with antiserum to dopamine {beta}-hydroxylase [dopamine {beta}-monooxygenase; 3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase ({beta}-hydroxylating), EC 1.14.17.1 ], the enzyme converting dopamine to noradrenaline (norepinephrine). In guinea pigs the somatostatin immunoreactive material was found in almost two-thirds of all principal ganglion cells of the coeliac-superior mesenteric ganglion complex (anterior inferior part) and of the inferior mesenteric ganglion, but only in a few cells of the superior cervical ganglion. It appeared to be localized close to the Golgi complex. The present findings may represent a concomitant storage of a biogenic amine and a small peptide in a neuron. Because both noradrenaline and somatostatin may fulfill a role as a neurotransmitter or modulator, the sympathetic neurons described in this study may represent an example of mammalian nerve cells not conforming to Dale's hypothesis, i.e., the one neuronone transmitter concept.
关键词：amine precursor uptake and decarboxylation (APUD) concept ; Dale's principle ; peripheral peptide neurons