文章基本信息

标题：Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma
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作者：S P Staal ; J W Hartley ; W P Rowe 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1977
卷号：74
期号：7
页码：3065-3067
DOI：10.1073/pnas.74.7.3065
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Murine leukemia viruses capable of malignant transformation of mink tissue culture cells have been isolated from an AKR thymoma cell line and from a spontaneous reticulum cell sarcoma in an NIH Swiss mouse partially congenic for the AKR ecotropic virus-inducing locus Akv-2. In contrast to the recently described mink cell focus-inducing strains of murine leukemia virus, at least one of the two transforming strains is replication defective. Nonproducer mink cells carrying the genome of the transforming virus of AKR origin have been isolated, and pseudotype transforming viruses generated.