文章基本信息

标题：Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera
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作者：J A Levy ; J N Ihle ; O Oleszko 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1975
卷号：72
期号：12
页码：5071-5075
DOI：10.1073/pnas.72.12.5071
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A low-molecular-weight substance found naturally in mouse serum neutralizes mouse xenotropic C-type virus. It has no effect on endogenous ecotropic viruses. This neutralizing factor does not belong to the known immunogloblin classes, and its activity is not associated with the antivirus immunoglobulins that can be detected by radioimmunoprecipitation. Preparations of xenotropic virus absorb out this neutralizing activity in mouse sera. The specificity of this factor for X-tropic virus suggests that it represents a newly recognized type of response of the host to an endogenous virus. Its possible role in the regulation of endogenous C-type viruses is considered.