文章基本信息

标题：Plasmid interactions in Staphylococcus aureus: nonadditivity of compatible plasmid DNA pools
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作者：C Ruby ; R P Novick
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1975
卷号：72
期号：12
页码：5031-5035
DOI：10.1073/pnas.72.12.5031
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Six different Staphylococcus aureus plasmids have been examined for compatibility relationships and their intracellular DNA pools have been measured singly and in various combinations. All six were mutually compatible, but contrary to expectation, their intracellular DNA pools were not additive; instead, there appeared to be a maximum level of extrachromosomal DNA that could be supported by the cell, and the plasmids studied approached this level individually as well as in varous combinations. One exception was encountered: a plasmid encoding kanamycin/neomycin resistance was present in a small but constant number of copies regardless of the presence of other plasmids.