文章基本信息

标题：Activation of T and B lymphocytes in vitro: presence of beta2-microblobulin determinants on allogeneic effect factor
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作者：D Armerding ; R T Kubo ; H M Grey 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1975
卷号：72
期号：11
页码：4577-4581
DOI：10.1073/pnas.72.11.4577
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The biologically acitve entity termed allogeneic effect factor, which is produced by alloantigen-activated T cells and has been shown to regulate triggering and differentiation of B lymphocytes in vitro, has previously been demonstrated to possess antigenic determinants coded by genes in the I region of the H-2 gene complex of the mouse. The studies presented here provide evidence that allogeneic effect factor also possesses antigenic determinants identical or cross-reactive with beta2-microglobulin. These observations suggest an important role for beta2-microglobulin in the mechanism of cell-cell interactions and the consequences of such interactions on lymphocyte triggering and differentiation.