文章基本信息

标题：Cholinergic Augmentation of Lymphocyte-Mediated Cytotoxicity. A Study of the Cholinergic Receptor of Cytotoxic T Lymphocytes
本地全文：下载
作者：Terry B. Strom ; Arthur J. Sytkowski ; Charles B. Carpenter 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：4
页码：1330-1333
DOI：10.1073/pnas.71.4.1330
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Cholinergic agonists have previously been shown to augment the ability of sensitized lymphocytes to injure cells bearing the sensitizing alleantigens. The cholinergic receptor of the attacking lymphocyte population has been studied with pharmacological manipulation of an in vitro system that quantitates the injury mediated by sensitized attacking cells upon target cells. The data reveal that muscarinic ligands are several orders of magnitude more potent than nicotinic agents in altering cytotoxicity.
关键词：cGMP ; muscarinic agents ; nicotinic agents