文章基本信息

标题：Adriamycin and Daunorubicin Inhibition of Mutant T4 DNA Polymerases
本地全文：下载
作者：Myron F. Goodman ; Maurice J. Bessman ; Nicholas R. Bachur 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：4
页码：1193-1196
DOI：10.1073/pnas.71.4.1193
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The anticancer drugs, adriamycin and daunorubicin, as well as two other DNA reagents, ethidium bromide and 9-aminoacridine, all exert a differential inhibitory effect on nucleotide incorporation for purified DNA polymerases induced by mutant and wild-type bacteriophage T4. When compared with DNA polymerase of wild-type phage, antimutator enzymes are inhibited to a far greater extent and mutator enzymes to a lesser extent. In contrast, the polymerase-associated 3'-exonuclease activities of wild type and mutants are also inhibited by the compounds but nondifferentially.
关键词：anthracycline antibiotics ; DNA polymerases ; mutator-antimutator genes