文章基本信息

标题：The Acquisition of Specificity in Cutaneous Sensory Neurons: A Reconsideration of the Integumental Specification Hypothesis
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作者：Joseph H. Sklar ; R. K. Hunt
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：12
页码：3684-3688
DOI：10.1073/pnas.70.12.3684
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Neuronal specificity in cutaneous sensory nerve cells has been postulated to arise from "inductive interactions" between the cell's randomly outgrown peripheral neurite and local biochemical markers in the skin. Here was apply this integumental specification hypothesis to data recently obtained on the wiping-reflex behavior of frogs skin-grafted at various times during larval life. Deductions are generated about the developmental time course of the postulated nerve-skin interactions and two predictions are formulated and tested. Because the results of serial skin rotation experiments contradict the predictions, we conclude that the currently held hypothesis must be seriously questioned.
关键词：dorsal root ganglion cells ; reflex development ; skin grafts ; Rana pipiens tadpoles