文章基本信息

标题：Poly(Inosinic Acid)·Poly(Cytidylic Acid) Inhibition of DNA Synthesis in Synchronized HeLa Cells
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作者：C. T. Teng ; M. C. Chen ; L. D. Hamilton 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：12
页码：3904-3908
DOI：10.1073/pnas.70.12.3904
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Inhibition by double-stranded polyribonucleotides of DNA synthesis in synchronized HeLa cultures is dose- and time-dependent. Inhibition by poly(I{middle dot}C) primarily affected late G1 and early S phases of the cell cycle. Single-stranded polynucleotides, native calf-thymus DNA, and yeast RNA had no effect. Radioautography showed that after 2-hr exposure the synthetic polyribonucleotides were predominantly inside the nucleus. The results extend the spectrum of action of double-stranded RNA.
关键词：synthetic polynucleotide ; cell cycle ; radioautography