首页    期刊浏览 2024年12月05日 星期四
登录注册

文章基本信息

  • 标题:Molecular Basis of the Biological Function of Molybdenum. The Relationship between Sulfite Oxidase and the Acute Toxicity of Bisulfite and SO2
  • 本地全文:下载
  • 作者:Harvey J. Cohen ; Robert T. Drew ; Jean L. Johnson
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1973
  • 卷号:70
  • 期号:12
  • 页码:3655-3659
  • DOI:10.1073/pnas.70.12.3655
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The administration of tungsten to rats maintained on a low molybdenum diet resulted in a dose- and time-dependent loss of sulfite oxidase (EC 1.8.3.1 ) and xanthine oxidase (EC 1.2.3.2 ) activities and hepatic molybdenum. These tungsten-treated animals appeared healthy, but were more susceptible to bisulfite toxicity. The median lethal dose for intraperitoneal bisulfite was found to be 181 mg of NaHSO3 per kg for the animals deficient in sulfite oxidase, compared to 473 mg/kg for normal rats. The survival time of rats exposed to SO2 at concentrations of 590 ppm and higher was seen to be inversely related to the level of SO2. At 590 ppm and 925 ppm, control animals displayed symptoms of severe respiratory toxicity before death. At 2350 ppm of SO2, death was preceded by seizures and prostration, symptoms observed with the systemic toxicity of injected bisulfite. At 590 ppm, animals deficient in sulfite oxidase were indistinguishable from control animals. However, at 925 ppm and 2350 ppm, the deficient animals displayed symptoms of systemic toxicity and had much shorter survival times. It is concluded that sulfite oxidase is instrumental in counteracting the toxic systemic effects of bisulfite, either injected or derived from respired SO2. Respiratory death probably results from the toxicity of gaseous SO2 before absorption as bisulfite and cannot be alleviated by sulfite oxidase. Sulfite oxidase does not appear to be inducible by either bisulfite or SO2.
  • 关键词:rat ; tungsten ; molybdenum deficiency ; systemic and respiratory toxicity ; enzyme induction
国家哲学社会科学文献中心版权所有