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标题：Relapsing fever Borrelia binds to neolacto glycans and mediates rosetting of human erythrocytes
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作者：Betty P. Guo ; Susann Teneberg ; Robert Münch 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：46
页码：19280-19285
DOI：10.1073/pnas.0905470106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A hallmark of acute relapsing fever borreliosis is severe bacteremia. Some Borrelia species, such as B. duttonii and B. crocidurae, associate with erythrocytes and induce aggregation recognized as erythrocyte rosetting. Erythrocyte rosettes contribute to disease severity by increased tissue invasiveness (such as invasion of CNS and encephalitis), hemorrhaging, and reduced blood flow in affected microcapillaries. Here we report that relapsing fever Borrelia binds to neolacto (Gal{beta}4GlcNAc{beta}3Gal{beta}4Glc{beta}1)-carrying glycoconjugates that are present on human erythrocytes. This interaction is of low affinity but is compensated for by the multivalency of neo-lacto-oligosaccharides on the erythrocyte cell surface. Hence, the protein-carbohydrate interaction is dependent on multivalent neolacto-glycans to mediate binding.
关键词：adhesion ; carbohydrate ; glycosphingolipids ; lacto-N-neotetraose ; red blood cells