文章基本信息

标题：The autophagy machinery is required to initiate hepatitis C virus replication
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作者：Marlène Dreux ; Pablo Gastaminza ; Stefan F. Wieland 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：33
页码：14046-14051
DOI：10.1073/pnas.0907344106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：In addition to its cellular homeostasis function, autophagy is emerging as a central component of antimicrobial host defense against diverse infections. To counteract this mechanism, many pathogens have evolved to evade, subvert, or exploit autophagy. Here, we report that autophagy proteins (i.e., Beclin-1, Atg4B, Atg5, and Atg12) are proviral factors required for translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but they are not required once infection is established. These results illustrate a previously unappreciated role for autophagy in the establishment of a viral infection and they suggest that different host factors regulate the translation of incoming viral genome and translation of progeny HCV RNA once replication is established.
关键词：flaviviridae ; autophagosome ; LC3 ; ATG ; translation