文章基本信息

标题：A role for the TGFβ-Par6 polarity pathway in breast cancer progression
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作者：Alicia M. Viloria-Petit ; Laurent David ; Jun Yong Jia 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：33
页码：14028-14033
DOI：10.1073/pnas.0906796106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The role of polarity signaling in cancer metastasis is ill defined. Using two three-dimensional culture models of mammary epithelial cells and an orthotopic mouse model of breast cancer, we reveal that Par6 signaling, which is regulated directly by TGF{beta
关键词：epithelial-to-mesenchymal transition ; cell polarity ; metastasis ; tumor invasion ; epithelial plasticity