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  • 标题:Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection
  • 本地全文:下载
  • 作者:Jonah B. Sacha ; Juan P. Giraldo-Vela ; Matthew B. Buechler
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2009
  • 卷号:106
  • 期号:24
  • 页码:9791-9796
  • DOI:10.1073/pnas.0813106106
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The precise immunological role played by CD4+ T cells in retroviral infections is poorly defined. Here, we describe a new function of these cells, the elimination of retrovirus-infected macrophages. After experimental CD8+ cell depletion, elite controlling macaques with set-point viral loads [≤]500 viral RNA copies/mL mounted robust Gag- and Nef-specific CD4+ T cell responses during reestablishment of control with [≥]54% of all virus-specific CD4+ T cells targeting these 2 proteins. Ex vivo, these simian immunodeficiency virus (SIV)-specific CD4+ T cells neither recognized nor suppressed viral replication in SIV-infected CD4+ T cells. In contrast, they recognized SIV-infected macrophages as early as 2 h postinfection because of presentation of epitopes derived from virion-associated Gag and Nef proteins. Furthermore, virus-specific CD4+ T cells displayed direct effector function and eliminated SIV-infected macrophages. These results suggest that retrovirus-specific CD4+ T cells may contribute directly to elite control by inhibiting viral replication in macrophages.
  • 关键词:antigen processing and presentation ; HIV
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