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  • 标题:Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways
  • 本地全文:下载
  • 作者:Shaista Naqvi ; Changfu Zhu ; Gemma Farre
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2009
  • 卷号:106
  • 期号:19
  • 页码:7762-7767
  • DOI:10.1073/pnas.0901412106
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Vitamin deficiency affects up to 50% of the world's population, disproportionately impacting on developing countries where populations endure monotonous, cereal-rich diets. Transgenic plants offer an effective way to increase the vitamin content of staple crops, but thus far it has only been possible to enhance individual vitamins. We created elite inbred South African transgenic corn plants in which the levels of 3 vitamins were increased specifically in the endosperm through the simultaneous modification of 3 separate metabolic pathways. The transgenic kernels contained 169-fold the normal amount of {beta}-carotene, 6-fold the normal amount of ascorbate, and double the normal amount of folate. Levels of engineered vitamins remained stable at least through to the T3 homozygous generation. This achievement, which vastly exceeds any realized thus far by conventional breeding alone, opens the way for the development of nutritionally complete cereals to benefit the world's poorest people.
  • 关键词:folic acid ; metabolic engineering ; transgenic maize ; vitamin A fortification ; vitamin C
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