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标题：A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures
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作者：Claude M. Schofield ; Max Kleiman-Weiner ; Uwe Rudolph 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：18
页码：7630-7635
DOI：10.1073/pnas.0811326106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Neural inhibition within the thalamus is integral in shaping thalamocortical oscillatory activity. Fast, synaptic inhibition is primarily mediated by activation of heteropentameric GABAA receptor complexes. Here, we examined the synaptic physiology and network properties of mice lacking GABAA receptor {alpha}3, a subunit that in thalamus is uniquely expressed by inhibitory neurons of the reticular nucleus (nRT). Deletion of this subunit produced a powerful compensatory gain in inhibitory postsynaptic response in nRT neurons. Although, other forms of inhibitory and excitatory synaptic transmission in the circuit were unchanged, evoked thalamic oscillations were strongly dampened in {alpha}3 knockout mice. Furthermore, pharmacologically induced thalamocortical absence seizures displayed a reduction in length and power in {alpha}3 knockout mice. These studies highlight the role of GABAergic inhibitory strength within nRT in the maintenance of thalamic oscillations, and demonstrate that inhibitory intra-nRT synapses are a critical control point for regulating higher order thalamocortical network activity.
关键词：benzodiazepine ; epilepsy ; inhibition ; knockout