文章基本信息

标题：Detailed recollection of remote autobiographical memory after damage to the medial temporal lobe
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作者：C. Brock Kirwan ; Peter J. Bayley ; Veronica V. Galván 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2008
卷号：105
期号：7
页码：2676-2680
DOI：10.1073/pnas.0712155105
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Previous findings of intact remote autobiographical memory in patients with medial temporal lobe damage have been questioned on the grounds that the narrative recollections were impoverished and fact-like and that the methods were not sufficiently sensitive to detect an impairment. We adopted a newer method, the Autobiographical Interview [Levine B, Svoboda E, Hay JF, Winocur G, Moscovitch M (2002) Psychol Aging 17:677-689], which uses extensive probing to elicit an average of 50 or more details per memory (in contrast to the {approx}20 details per memory elicited with previous methods). We found that autobiographical recollection was impaired in patients with medial temporal lobe damage when memories were drawn from the recent past but fully intact when memories were drawn from the remote past. Impaired remote autobiographical memory, which has sometimes been reported with this and other tests, is likely caused by significant damage outside the medial temporal lobe.
关键词：amnesia ; consolidation ; hippocampus ; retrograde