文章基本信息

标题：The phasevarion: A genetic system controlling coordinated, random switching of expression of multiple genes
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作者：Yogitha N. Srikhanta ; Tina L. Maguire ; Katryn J. Stacey 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2005
卷号：102
期号：15
页码：5547-5551
DOI：10.1073/pnas.0501169102
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Several host-adapted bacterial pathogens contain methyltransferases associated with type III restriction-modification (R-M) systems that are subject to reversible, high-frequency on/off switching of expression (phase variation). To investigate the role of phase-variable expression of R-M systems, we made a mutant strain lacking the methyltransferase (mod) associated with a type III R-M system of Haemophilus influenzae and analyzed its phenotype. By microarray analysis, we identified a number of genes that were either up- or down-regulated in the mod mutant strain. This system reports the coordinated random switching of a set of genes in a bacterial pathogen and may represent a widely used mechanism.
关键词：DNA methyltransferase ; Haemophilus influenzae ; phase variation