文章基本信息

标题：Tissue-specific codon usage and the expression of human genes
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作者：Joshua B. Plotkin ; Harlan Robins ; Arnold J. Levine 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：34
页码：12588-12591
DOI：10.1073/pnas.0404957101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A diverse array of mechanisms regulate tissue-specific protein levels. Most research, however, has focused on the role of transcriptional regulation. Here we report systematic differences in synonymous codon usage between genes selectively expressed in six adult human tissues. Furthermore, we show that the codon usage of brain-specific genes has been selectively preserved throughout the evolution of human and mouse from their common ancestor. Our findings suggest that codon-mediated translational control may play an important role in the differentiation and regulation of tissue-specific gene products in humans.